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Metabolome

Definition
AI-generated

The metabolome is the complete set of small-molecule metabolites present in a biosample (e.g. plasma, urine), as profiled by mass spectrometry or NMR. It reflects downstream biochemistry of genotype, diet, microbiome, and environment.

Topics
Sequencing and omics tech
Related
Expression Quantitative Trait Locus (eQTL) Genome-Wide Association Study (GWAS) Genomics

Why it matters in GWAS

Metabolite GWAS (mGWAS) links genetic variants to biochemical traits, aiding pathway interpretation of disease associations and biomarker discovery.

Example usage

"A replication step checks whether Metabolome assumptions remain stable across cohorts."

Expression Quantitative Trait Locus (eQTL) Genome-Wide Association Study (GWAS) Genomics Lipid Quantitative Trait Locus Metabolite Quantitative Trait Locus (metaboQTL) Multi-Omics Polygenic Risk Score (PRS) Trait
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Kettunen J, et al. (2016). Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA. Nat Commun.
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