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High LD Regions

Definition
AI-generated

High LD regions are genomic segments where linkage disequilibrium (LD) remains strong over long physical distances—often megabases—so that genotyped variants tag many neighbors.

Topics
Population genetics
Related
Extended MHC Region Fine-Mapping Genome-Wide Association Study (GWAS)

Why it matters in GWAS

Association peaks in high-LD regions are hard to resolve to a single causal variant without fine-mapping, long-range haplotype information, or functional data; polygenic score and meta-analysis pipelines must handle duplicated signal and long-range correlation. The HLA / MHC locus is the canonical example in human studies.

Example usage

"The signal spanned one of the known high LD regions, so we conditioned on stepwise SNPs before claiming a second independent hit."

Extended MHC Region Fine-Mapping Genome-Wide Association Study (GWAS) HLA Region Linkage Disequilibrium (LD) MHC Region Recombination
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Slatkin M. (2008). Linkage disequilibrium—understanding the evolutionary past and mapping the future. Nat Rev Genet.
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