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Genotype Dosage

Definition
AI-generated

Genotype dosage is the expected count of a counted allele at a variant (often 0–2 in diploids), computed from imputed posterior genotype probabilities or from explicit dosage fields in formats such as VCF DS or Oxford BGEN.

Topics
Core genetics
URL
https://www.cog-genomics.org/plink/2.0/input#dosage%5Fimport%5Fsettings
Related
Allele BGEN Genotype

Why it matters in GWAS

Dosages feed association models (e.g. PLINK 2 --glm), allele frequency and MAC filters, and PCA/GRM when software is dosage-aware, improving power and calibration after imputation compared with arbitrary hard-call thresholds.

Example usage

"At this locus, Genotype Dosage annotations were used to prioritize plausible biological mechanisms."

Allele BGEN Genotype Genotype Imputation Imputation Quality Metric Minor Allele Frequency (MAF) PLINK Single Nucleotide Polymorphism (SNP)
Related-term network

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Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • PLINK 2.0 dosage import settings: https://www.cog-genomics.org/plink/2.0/input#dosage%5Fimport%5Fsettings
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