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Homolog

Definition
AI-generated

A homolog is a homologous gene, sequence, chromosome, or trait—one that shares common ancestry with the feature being compared.

Topics
Evolutionary genetics
Related
Homology Homologous Ortholog

Why it matters in GWAS

Comparative maps and conservation tracks relate human GWAS loci to model-organism homologs; confusing homologs with sequence-similar but non-homologous regions misroutes follow-up.

Example usage

"We tested whether the mouse homolog of the GWAS gene reproduced the obesity association in a knockout model."

Homology Homologous Ortholog Paralog
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Koonin EV. (2005). Orthologs, paralogs, and evolutionary genomics. Annu Rev Genet.
← Homogamy Homologous →

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