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Hazard Ratio (HR)

Definition
AI-generated

A hazard ratio compares the instantaneous event rate between groups in a time-to-event model, usually a Cox proportional hazards model.

Topics
Regression and multivariate statistics
Related
Cox Proportional Hazards Model Effect Size Hazard

Why it matters in GWAS

Biobank analyses increasingly use survival or age-at-onset outcomes instead of simple case-control status. Hazard ratios capture timing information and censoring, so they are not interchangeable with odds ratios or relative risks even when all three are greater than 1.

Example usage

"The variant was associated with incident coronary disease with HR = 1.12 per effect allele in a Cox model."

Cox Proportional Hazards Model Effect Size Hazard Measure of Effect Odds Ratio (OR) Relative Risk (RR) Risk Stratification Survival Analysis Time-to-Event
Related-term network

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Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Cox DR. (1972). Regression models and life-tables. J R Stat Soc Series B.
  • GWASTutorial: Measure of effect.
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