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Fixation index (FST)

Definition
AI-generated

FST is a fixation index that measures allele frequency differentiation between populations.

Topics
Population genetics
Synonyms
Fixation index (in the between-population sense) Wright's FST
Related
Ancestry F-Statistics Population Stratification

Why it matters in GWAS

FST helps quantify how strongly allele frequencies differ across ancestry groups, which matters for population stratification, portability of PRS, and interpretation of cross-population signals.

Example usage

"Variants with high FST between the populations were examined as markers of ancestry differentiation."

Ancestry F-Statistics Population Stratification
Related-term network

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Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Weir BS, Cockerham CC. (1984). Estimating F-statistics for the analysis of population structure. Evolution.
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