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Complex Disease

Definition
AI-generated

A complex disease (or complex trait) is influenced by many genetic variants of small to moderate effect together with environment and behavior, rather than following simple Mendelian inheritance from one or a few genes.

Topics
Core genetics
Related
Omnigenic Model Genome-Wide Association Study (GWAS) Heritability

Why it matters in GWAS

GWAS was designed to detect common and low-penetrance contributors to complex disease; findings motivate polygenic models, pathway analyses, and comparison with rare Mendelian forms of related phenotypes.

Example usage

"Type 2 diabetes behaves as a complex disease with hundreds of associated loci of small individual effect."

Omnigenic Model Genome-Wide Association Study (GWAS) Heritability Mendelian Disease Missing Heritability Polygenic Risk Score (PRS)
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Boyle EA, Li YI, Pritchard JK. (2017). An expanded view of complex traits: from polygenic to omnigenic. Cell.
← Complementary DNA (cDNA) Complex trait →

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