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Complex trait

Definition
AI-generated

A trait influenced by many genetic and environmental factors; typically polygenic with no single Mendelian locus explaining most risk.

Topics
Core genetics
Related
Polygenic Risk Score Heritability Omnigenic Model

Why it matters in GWAS

These concepts shape how we expect variants to act (penetrance, heterogeneity, threshold models) and how GWAS signals should be interpreted alongside family-based evidence.

Example usage

"Height was modeled as a complex trait influenced by many loci of small effect plus environmental factors."

Polygenic Risk Score Heritability Omnigenic Model
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Griffiths AJF, et al. (2015). An Introduction to Genetic Analysis. W. H. Freeman.
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