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Codon

Definition
AI-generated

A codon is a contiguous triplet of nucleotides in mRNA (or the corresponding DNA coding sequence) that specifies one amino acid or a translation stop signal during protein synthesis.

Topics
Molecular biology
Related
Antisense Anticodon Central Dogma

Why it matters in GWAS

Coding variants are often annotated by how they change codons (missense, nonsense, synonymous), which guides functional interpretation of exome-wide and rare-variant association signals.

Example usage

"The rare variant introduced a premature stop codon in exon 7, predicted to truncate the protein."

Antisense Anticodon Central Dogma Missense Variant Nonsense Variant Open Reading Frame (ORF) Synonymous Variant
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Alberts B, et al. (2015). Molecular Biology of the Cell. 6th ed. Garland Science.
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