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Antisense

Definition
AI-generated

The antisense strand of DNA is the template strand read by RNA polymerase to produce RNA complementary to the non-template “sense” strand.

Topics
Molecular biology
Related
Antisense oligonucleotide (ASO) Anticodon Codon

Why it matters in GWAS

Strand and transcript orientation affect variant annotation (e.g. which allele is “reference” on the forward genomic strand) and integration with RNA-level data used in molecular QTL and functional follow-up.

Example usage

"We confirmed the effect allele on the genomic forward strand matched the antisense template used for cDNA synthesis."

Antisense oligonucleotide (ASO) Anticodon Codon Reference Allele RNA Sequencing (RNA-seq) Transcript Assembly
Related-term network

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References

  • Lodish H, et al. (2021). Molecular Cell Biology. 9th ed. W. H. Freeman.
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