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Top Variant

Definition
AI-generated

Top variant is an informal term for the variant with the strongest statistical association in a region or analysis, usually the one with the smallest p-value.

Topics
GWAS
Related
Lead Variant Sentinel Variant Index Variant

Why it matters in GWAS

This wording is common in slides, figure captions, and quick summaries. In formal writing, authors often use "lead variant" or "sentinel variant" for the same statistical idea.

Example usage

"The top variant at this locus reached genome-wide significance, but high LD prevented direct causal assignment."

Lead Variant Sentinel Variant Index Variant Significance Level P-value Linkage Disequilibrium (LD)
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Uffelmann E, et al. (2021). Genome-wide association studies. Nat Rev Methods Primers. https://doi.org/10.1038/s43586-021-00056-9
  • Kamatani Y, et al. (2010). Genome-wide association study of hematological and biochemical traits in a Japanese population. Nat Genet. https://doi.org/10.1038/ng.531
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