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Short Tandem Repeat (STR)

Definition
AI-generated

A short tandem repeat is a tandem repeat with a short repeated motif, commonly 1 to 6 base pairs long.

Topics
Core genetics
Related
Microsatellite Repeat Expansion Tandem Repeat

Why it matters in GWAS

STRs can affect gene regulation or protein sequence and may explain signals that are poorly tagged by nearby SNPs.

Example usage

"The fine-mapped interval included an STR that was imputed poorly from surrounding SNPs."

Microsatellite Repeat Expansion Tandem Repeat Variable Number Tandem Repeat (VNTR)
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Gymrek M. (2017). A genomic view of short tandem repeats. Curr Opin Genet Dev.
← Short-Read Sequencing Significance level →

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