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Rao score test

Definition
AI-generated

Uses score and Fisher info avoiding full Hessian—fast approximations in some genome-wide scans.

Why it matters in GWAS

Statistical concepts underpin GWAS significance, effect estimation, relatedness random effects, multiple testing, fine-mapping priors, and post-GWAS multivariate methods.

Example usage

"The analysis uses Rao score test to quantify associations and compare alternative hypotheses."

References

  • Casella G, Berger RL. (2002). Statistical Inference. Duxbury Press.
  • Wasserman L. (2004). All of Statistics. Springer.

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