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Read tag

Definition
AI-generated

A read tag is the sequenced segment that records a defined position on a library molecule in short-tag assays—commonly the capped 5′ end in CAGE—so that alignments mark features such as transcription start sites rather than full-length transcripts.

Topics
Sequencing and omics tech
Plural
read tags
Related
Sequence Alignment/Map (SAM) Read Read mapping

Why it matters in GWAS

Atlas and annotation resources built from 5′-tag data inform whether variants fall near active promoters or TSS usage peaks; knowing what the tag represents avoids conflating TSS signal with body or intronic read coverage from standard RNA-seq.

Example usage

"CAGE read tags were aggregated into tag clusters to call dominant transcription start sites near the GWAS locus."

Sequence Alignment/Map (SAM) Read Read mapping Cap Analysis of Gene Expression (CAGE-seq) Short Read Sequencing Transcription Start Site (TSS)
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Shiraki T, et al. (2003). Cap analysis gene expression for high-throughput analysis of transcriptional starting point and identification of promoter usage. Proc Natl Acad Sci USA.
  • Li H, et al. (2009). The Sequence Alignment/Map format and SAMtools. Bioinformatics. https://doi.org/10.1093/bioinformatics/btp352
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