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Population Expansion

Definition
AI-generated

Population expansion is sustained growth in census or effective population size, which tends to increase genetic diversity, shorten haplotypes relative to equilibrium expectations, and skew the site-frequency spectrum toward rare variants—unless offset by selection or structure.

Topics
Population genetics
Related
Coalescent Theory Gene Flow Genetic Bottleneck

Why it matters in GWAS

Demographic expansion versus contraction affects calibration of genomic inflation, LD models, imputation panels, and neutral simulations used in fine-mapping and selection scans; human out-of-Africa expansion is a standard backdrop for global allele-frequency structure.

Example usage

"Cross-cohort analyses modeled Population Expansion to improve transferability and reduce population-structure confounding."

Coalescent Theory Gene Flow Genetic Bottleneck Natural Selection Population Stratification
Related-term network

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References

  • Wakeley J. (2009). Coalescent Theory: An Introduction. Roberts & Company.
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