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Phylogenetics

Definition
AI-generated

Inference of evolutionary trees or networks from heritable character data—often molecular sequences.

Why it matters in GWAS

Population structure, demographic history, and mating patterns affect allele frequencies, LD, relatedness, and cross-cohort portability—central to GWAS design and interpretation.

Example usage

"Downstream interpretation uses Phylogenetics to connect statistical signals with biological context."

References

  • Hartl DL, Clark AG. (2007). Principles of Population Genetics. Sinauer Associates.
  • Jobling MA, Hurles ME, Tyler-Smith C. (2013). Human Evolutionary Genetics. Garland Science.

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