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Kinship Coefficient

Definition
AI-generated

The kinship coefficient φ between two individuals is the probability that two alleles sampled at random (one from each individual at a locus) are identical by descent.

Topics
Population genetics
Related
Genetic Relationship Matrix (GRM) Identity by Descent (IBD) KING-Robust Kinship

Why it matters in GWAS

Kinship enters the genetic relationship matrix for linear mixed models, drives relatedness filtering thresholds, and connects to the relatedness coefficient r = 2φ used in screening.

Example usage

"Estimated Kinship Coefficient was used to identify close relatives before association testing."

Genetic Relationship Matrix (GRM) Identity by Descent (IBD) KING-Robust Kinship Inbreeding Coefficient (F) Relatedness Linear Mixed Model (LMM)
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Manichaikul A, et al. (2010). Robust relationship inference in genome-wide association studies. Bioinformatics.
  • GWASTutorial: Relatedness and sample structure.
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