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Insert size

Definition
AI-generated

Insert size is the length of the sequenced DNA fragment between the innermost bases of a read pair in paired-end sequencing (sometimes called inner distance or fragment length depending on convention).

Topics
Sequencing Data Analysis
Related
Paired-End Sequencing Read mapping Whole-Genome Sequencing (WGS)

Why it matters in GWAS

Insert size informs library QC, structural variant sensitivity, and duplicate marking; extreme or multimodal distributions can flag batch effects or sample swaps that distort association analyses.

Example usage

"Insert size metrics were summarized per lane to detect outliers before joint genotyping."

Paired-End Sequencing Read mapping Whole-Genome Sequencing (WGS)
Related-term network

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Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Illumina. Understanding Illumina quality scores for sequencing data.
← Informed Consent Insertion →

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