Skip to content

Non-effect Allele

Definition
AI-generated

The non-effect allele is the other allele at a variant when one allele is designated as the effect allele for reporting signed effects (beta or log odds ratio).

Topics
Core genetics GWAS
Related
Effect Allele Non-risk Allele Risk Allele

Why it matters in GWAS

Effect direction is defined relative to the effect allele; swapping to the non-effect allele flips the sign of beta or log odds ratio. Clear labeling prevents harmonization and meta-analysis errors.

Example usage

"We verified that each study used the same effect allele and corresponding non-effect allele before meta-analysis."

Effect Allele Non-risk Allele Risk Allele Reference Allele Alternative Allele
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

← Non-coding RNA (ncRNA) Non-homologous end joining (NHEJ) →

Last updated (UTC · Git history)