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Multi-Ancestry Transcriptome-Wide Association Study

Definition
AI-generated

A multi-ancestry transcriptome-wide association study extends TWAS by combining expression prediction models and/or summary statistics across ancestry groups, aiming to improve gene discovery and fine-mapping of regulatory mechanisms when cis-LD and eQTL panels differ between populations.

Topics
Post-GWAS
Synonyms
Trans-ancestry TWAS
Related
TWAS Fine-Mapping Expression Quantitative Trait Locus (eQTL) Genotype-Tissue Expression (GTEx)

Why it matters in GWAS

Single-ancestry TWAS can miss genes whose regulatory architecture is poorly tagged in the training panel; multi-ancestry methods increase power for diverse target cohorts and align with broader goals of equitable post-GWAS interpretation.

Example usage

"Multi-Ancestry Transcriptome-Wide Association Study estimates were incorporated to improve portability and calibration across diverse cohorts."

TWAS Fine-Mapping Expression Quantitative Trait Locus (eQTL) Genotype-Tissue Expression (GTEx) Multi-Ancestry Fine-Mapping Trans-Ancestry GWAS Transcriptome-Wide Association Study (TWAS)
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References

  • Li Z, et al. (2022). METRO: Multi-ancestry transcriptome-wide association studies for powerful gene-trait association detection. Am J Hum Genet.
  • Chen F, et al. (2023). Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing. Nat Genet.
  • Kuchenbaecker K, Navoly G. (2026). Ancestral diversity in complex disease genetics: from discovery to translation. Nat Rev Genet. https://doi.org/10.1038/s41576-025-00921-3
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