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Genotype-Tissue Expression (GTEx)

Definition
AI-generated

GTEx is a project that profiles gene expression and regulatory variation across many human tissues to map expression quantitative trait loci (eQTLs) and related molecular effects.

Topics
Cohorts and databases
Synonyms
Genotype-Tissue Expression
URL
https://gtexportal.org/home/
Related
Colocalization Expression Quantitative Trait Locus (eQTL) Genome-Wide Association Study (GWAS)

Why it matters in GWAS

GTEx is widely used to connect GWAS loci to target genes and tissues through colocalization, eQTL overlap, and transcriptome-informed analyses.

Example usage

"We used GTEx whole-blood eQTLs to prioritize candidate genes at associated loci."

Colocalization Expression Quantitative Trait Locus (eQTL) Genome-Wide Association Study (GWAS) Human Cell Atlas Noncoding Variant Single-Cell Expression Quantitative Trait Locus (sc-eQTL) Transcriptome-Wide Association Study (TWAS) Variant Annotation
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Cuomo ASE, Nathan A, Raychaudhuri S, et al. (2023). Single-cell genomics meets human genetics. Nat Rev Genet. https://doi.org/10.1038/s41576-023-00599-5
  • GTEx Consortium. (2020). The GTEx Consortium atlas of genetic regulatory effects across human tissues. Science.
← Genome-based Restricted Maximum Likelihood (GREML) Gene Transfer Format (GTF) →

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