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Multi-allelic variant

Definition
AI-generated

A multi-allelic variant is a locus with more than one alternate allele in a cohort or reference context.

Topics
Sequencing Data Analysis
Related
Allele count (AC) Biallelic Variant Variant normalization

Why it matters in GWAS

Multi-allelic sites complicate association encoding, imputation, and collapsing; many pipelines split or left-normalize before testing.

Example usage

"Each multi-allelic variant was split into biallelic records for GWAS compatibility."

Allele count (AC) Biallelic Variant Variant normalization
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Danecek P, et al. (2011). The variant call format and VCFtools. Bioinformatics.
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