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Biomarker

Definition
AI-generated

A biomarker is a measurable characteristic (molecular, imaging, physiologic, or behavioral) that indicates a normal or pathologic process, or a response to intervention.

Topics
Precision medicine
Related
Companion Diagnostics Expression Quantitative Trait Locus (eQTL) Genome-Wide Association Study (GWAS)

Why it matters in GWAS

GWAS and QTL studies nominate candidate biomarkers (e.g. variants linked to protein levels or disease risk); moving from association to clinical use requires replication, calibration across ancestries, and often orthogonal evidence (e.g. Mendelian randomization, functional assays).

Example usage

"The lead SNP was proposed as a biomarker for trial stratification after cross-cohort replication."

Companion Diagnostics Expression Quantitative Trait Locus (eQTL) Genome-Wide Association Study (GWAS) Molecular Diagnostics Polygenic Risk Score (PRS) Precision Medicine
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Strimbu K, Tavel JA. (2010). What are biomarkers? Curr Opin HIV AIDS.
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