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Microbiome

Definition
AI-generated

The microbiome is the community of microorganisms (bacteria, archaea, viruses, fungi) and their collective genomes in a habitat such as the gut, oral cavity, or skin, often profiled by 16S rRNA sequencing or shotgun metagenomics.

Topics
Epidemiology
Related
Exposome Genome-Wide Association Study (GWAS) Metagenomics

Why it matters in GWAS

Host genetics associates with microbiome composition (microbiome GWAS); joint modeling of host genotypes and microbial features tests gene–environment interactions relevant to metabolism, immunity, and drug response.

Example usage

"We tested whether BMI-associated SNPs also predicted gut microbiome beta diversity after covariate adjustment."

Exposome Genome-Wide Association Study (GWAS) Metagenomics Metabolome Multi-Omics
Related-term network

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References

  • Kurilshikov A, et al. (2021). Large-scale association analyses identify host factors influencing human gut microbiome composition. Nat Genet.
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