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KING-Robust Kinship

Definition
AI-generated

KING-robust kinship refers to relationship inference implemented in the KING method family, designed to remain reliable when population allele frequencies are estimated with error—unlike some classical estimators that assume accurate AFs.

Topics
Population genetics
URL
https://www.cog-genomics.org/plink/2.0/distance#make%5Fking
Related
Cryptic Relatedness Genetic Relationship Matrix (GRM) Identity by Descent (IBD)

Why it matters in GWAS

Large biobanks mix ancestries and often lack perfect AF estimates; KING-style metrics support duplicate detection, cryptic relatedness filtering, and choosing unrelated subsets for PCA or LMM without over-relying on a single homogeneous reference panel.

Example usage

"Estimated KING-Robust Kinship was used to identify close relatives before association testing."

Cryptic Relatedness Genetic Relationship Matrix (GRM) Identity by Descent (IBD) Kinship Coefficient PLINK Relatedness
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Manichaikul A, et al. (2010). Robust relationship inference in genome-wide association studies. Bioinformatics.
  • PLINK 2.0 KING: https://www.cog-genomics.org/plink/2.0/distance#make%5Fking
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