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MHC Region

Definition
AI-generated

The major histocompatibility complex (MHC) is a conserved genomic region—large and gene-dense in humans—whose hallmark genes encode molecules that display peptide antigens for immune recognition.

Topics
Population genetics
Related
Extended MHC Region Genome-Wide Association Study (GWAS) High LD Regions

Why it matters in GWAS

MHC associations appear across infection, autoimmunity, cancer immunology, and drug response; the same statistical challenges as the HLA region apply (allelic diversity, structural variation, long-range LD). Comparing results across species or using non-human references requires care when generalizing “MHC” labels.

Example usage

"The canine GWAS peak overlapped the MHC region, analogous to HLA associations in humans."

Extended MHC Region Genome-Wide Association Study (GWAS) High LD Regions HLA Region Linkage Disequilibrium (LD)
Related-term network

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Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Neefjes J, Jongsma ML, Paul P, Bakke O. (2011). Towards a systems understanding of MHC class I and MHC class II antigen presentation. Nat Rev Immunol.
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