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Fusion transcript

Definition
AI-generated

A fusion transcript is a chimeric RNA joining exonic sequences from two or more separate genes or loci, often from rearrangement, read-through, or trans-splicing; RNA-seq fusion callers detect these as split reads, spanning pairs, or assembled junction contigs.

Topics
Molecular biology Sequencing Data Analysis
Related
Chimeric read RNA Sequencing (RNA-seq) Structural Variant

Why it matters in GWAS

While germline GWAS focuses on common variation, fusion transcripts matter in tumor and rare-disease genomics that intersect with association studies of susceptibility; structural variant and expression integration can nominate driver mechanisms.

Example usage

"The RNA-seq pipeline flagged a BCR–ABL1 fusion transcript supporting the structural variant call."

Chimeric read RNA Sequencing (RNA-seq) Structural Variant Transcript
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Haas BJ, et al. (2019). Accuracy assessment of fusion transcript detection via read-mapping and de novo fusion transcript assembly-based methods. Genome Biol.
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