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CLIP-seq

Definition
AI-generated

CLIP-seq (crosslinking and immunoprecipitation sequencing) maps RNA–protein interaction sites by UV crosslinking, immunoprecipitation of the target protein, RNA fragmentation, and sequencing of bound RNA fragments, yielding nucleotide-resolution binding footprints.

Topics
Sequencing and omics tech
Related
Chromatin Gene expression RNA Sequencing (RNA-seq)

Why it matters in GWAS

CLIP-class assays annotate RBP binding and microRNA target sites in a cellular context, helping interpret noncoding variants that may alter RNA processing or stability tied to gene expression and splicing programs.

Example usage

"CLIP-seq peaks overlapped the GWAS credible set SNP in the 3′ UTR."

Chromatin Gene expression RNA Sequencing (RNA-seq)
Related-term network

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References

  • Hafner M, et al. (2010). Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. Cell.
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