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Wahlund Effect

Definition
AI-generated

The Wahlund effect is an apparent deficit of heterozygotes caused by analyzing a mixture of subpopulations with different allele frequencies as though they were a single random-mating population.

Topics
Population genetics
Related
Ancestry Hardy-Weinberg Equilibrium (HWE) Heterozygote Deficit

Why it matters in GWAS

It links HWE deviations to ancestry structure rather than assay error alone, which helps avoid overinterpreting departures from equilibrium during QC.

Example usage

"The observed heterozygote deficit was consistent with a Wahlund effect in the combined multi-ancestry sample."

Ancestry Hardy-Weinberg Equilibrium (HWE) Heterozygote Deficit Population Stratification
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References

  • Waples RS. (2015). Testing for Hardy-Weinberg proportions: have we lost the plot? J Hered.
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