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Volcano Plot

Definition
AI-generated

A volcano plot displays effect magnitude on one axis (often log2 fold change or another contrast) and statistical significance on the other (typically −log10 *p* or an FDR-adjusted equivalent), so features with large shifts and strong evidence appear in the upper corners.

Topics
Visualization
Related
False Discovery Rate (FDR) ggplot2 Manhattan Plot

Why it matters in GWAS

GWAS teams often work beside transcriptomic pipelines; volcano plots are the everyday QC and reporting figure for feature lists, thresholding, and discussing global calibration before drilling into locus-level Manhattan or pathway views.

Example usage

"The DESeq2 volcano plot showed about 800 genes above FDR 0.05 with clear separation of up- and downregulated arms."

False Discovery Rate (FDR) ggplot2 Manhattan Plot Matplotlib
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Love MI, et al. (2014). Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol.
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