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Sum of squares of residuals

Definition
AI-generated

Unexplained variation after fitting—RSS drops as predictors improve fit subject to overfitting risk.

Why it matters in GWAS

Statistical concepts underpin GWAS significance, effect estimation, relatedness random effects, multiple testing, fine-mapping priors, and post-GWAS multivariate methods.

Example usage

"A replication analysis checks whether assumptions tied to Sum of squares of residuals remain stable across cohorts."

References

  • Casella G, Berger RL. (2002). Statistical Inference. Duxbury Press.
  • Wasserman L. (2004). All of Statistics. Springer.

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