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PRSice-2

Definition
AI-generated

PRSice-2 is software for calculating polygenic scores from GWAS summary statistics and individual-level target genotypes, supporting large-scale workflows including clumping, multiple *P*-value inclusion thresholds, regression-based evaluation, and high-dimensional phenotype targets.

Topics
Post-GWAS
Synonyms
PRSice
URL
https://www.prsice.info/
Related
GWAS Summary Statistics LD Clumping PLINK

Why it matters in GWAS

It implements a widely used clumping-and-thresholding PRS pipeline and is a common reference implementation in applied and teaching settings.

Example usage

"We ran PRSice-2 with the base GWAS summary statistics and UK Biobank target genotypes across a range of P-value cutoffs."

GWAS Summary Statistics LD Clumping PLINK Polygenic Risk Score (PRS) PRS Base Cohort PRS Clumping and Thresholding PRS Target Cohort
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Choi SW, O'Reilly PF. (2019). PRSice-2: polygenic risk score software for biobank-scale data. Gigascience.
  • Choi SW, Mak TSH, O'Reilly PF. (2020). Tutorial: a guide to performing polygenic risk score analyses. Nat Protoc. https://doi.org/10.1038/s41596-020-0353-1
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