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PRS Base Cohort

Definition
AI-generated

The base cohort in polygenic score analysis is the discovery sample (or meta-analysis) from which GWAS summary statistics—effect sizes, *p*-values, and aligned alleles—are taken to define SNP weights.

Topics
Cohorts and databases
Synonyms
Discovery sample (PRS) Training GWAS (informal)
Related
Ancestry Genome-Wide Association Study (GWAS) GWAS Summary Statistics

Why it matters in GWAS

Base GWAS quality, ancestry, sample size, and trait definition determine which variants enter the PRS; winner’s curse and cryptic overlap with the target inflate apparent prediction unless designs preclude them.

Example usage

"Downstream interpretation uses PRS Base Cohort to connect statistical signals with biological context."

Ancestry Genome-Wide Association Study (GWAS) GWAS Summary Statistics Lassosum LDpred Polygenic Risk Score (PRS) PRS Clumping and Thresholding PRS Target Cohort PRSice-2 Winner's curse
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Choi SW, Mak TSH, O'Reilly PF. (2020). Tutorial: a guide to performing polygenic risk score analyses. Nat Protoc. https://doi.org/10.1038/s41596-020-0353-1
  • Dudbridge F. (2013). Power and predictive accuracy of polygenic risk scores. PLoS Genet.
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