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PRS Target Cohort

Definition
AI-generated

The target cohort in polygenic score analysis is the sample with individual-level genotypes (and usually phenotypes and covariates) on which the PRS is computed and evaluated—e.g. association of the score with the trait, variance explained, or stratification by score deciles.

Topics
Cohorts and databases
Synonyms
Validation sample (PRS) Application cohort (PRS)
Related
Ancestry Genotype Polygenic Risk Score (PRS)

Why it matters in GWAS

The target defines the population in which portability, calibration, and clinical or experimental utility are assessed; it should be independent of the base GWAS for unbiased performance and use ancestry-appropriate LD references for clumping when applicable.

Example usage

"A replication analysis checks whether assumptions tied to PRS Target Cohort hold across cohorts."

Ancestry Genotype Polygenic Risk Score (PRS) Polygenic Risk Score Portability PRS Base Cohort PRS Clumping and Thresholding PRSice-2 Principal Component Analysis (PCA)
Related-term network

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Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Choi SW, Mak TSH, O'Reilly PF. (2020). Tutorial: a guide to performing polygenic risk score analyses. Nat Protoc. https://doi.org/10.1038/s41596-020-0353-1
  • Dudbridge F. (2013). Power and predictive accuracy of polygenic risk scores. PLoS Genet.
← PRS Clumping and Thresholding PRSice-2 →

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