Skip to content

Exposome

Definition
AI-generated

The exposome is the complement to the genome: the totality of environmental, behavioral, and social exposures individuals experience across the life course, and their biological consequences.

Topics
Epidemiology
Related
Ancestry Bias Cohort

Why it matters in GWAS

Genetic discovery and polygenic scores are frequently interpreted as if risks were context-free; integrating exposome thinking clarifies gene–environment interaction, population-specific contexts, and why associations may not transfer across settings—goals emphasized in reviews of global precision medicine.

Example usage

"The methods explicitly include Exposome in the end-to-end analysis workflow."

Ancestry Bias Cohort Gene-Environment Interaction (GxE) Pan-Omics Polygenic Risk Score Portability Precision Medicine Precision Prevention
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Vermeulen R, Schymanski EL, Barabási AL, Miller GW. (2020). The exposome and health: where chemistry meets biology. Science.
  • Kuchenbaecker K, Navoly G. (2026). Ancestral diversity in complex disease genetics: from discovery to translation. Nat Rev Genet. https://doi.org/10.1038/s41576-025-00921-3
← Exploratory factor analysis (EFA) Expression Quantitative Trait Locus (eQTL) →

Last updated (UTC · Git history)