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Law of independent assortment

Definition
AI-generated

Alleles of different genes assort independently in gametes when loci are unlinked (Mendel’s second law; assumes no LD).

Topics
Core genetics
Related
Linkage Disequilibrium Recombination Gamete

Why it matters in GWAS

These concepts shape how we expect variants to act (penetrance, heterogeneity, threshold models) and how GWAS signals should be interpreted alongside family-based evidence.

Example usage

"A replication step checks whether Law of independent assortment assumptions remain stable across cohorts."

Linkage Disequilibrium Recombination Gamete
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Griffiths AJF, et al. (2015). An Introduction to Genetic Analysis. W. H. Freeman.
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