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Leave-one-out cross-validation

Definition
AI-generated

Extreme k-fold where each observation serves once as its own validation fold—expensive but nearly unbiased in small n.

Why it matters in GWAS

Statistical concepts underpin GWAS significance, effect estimation, relatedness random effects, multiple testing, fine-mapping priors, and post-GWAS multivariate methods.

Example usage

"A replication step checks whether Leave-one-out cross-validation assumptions remain stable across cohorts."

References

  • Casella G, Berger RL. (2002). Statistical Inference. Duxbury Press.
  • Wasserman L. (2004). All of Statistics. Springer.

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