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Inversion

Definition
AI-generated

An inversion is a structural variant in which a genomic segment is reversed in orientation relative to the reference genome.

Topics
Core genetics
Related
Linkage Disequilibrium (LD) Structural Variant Translocation

Why it matters in GWAS

Inversions can alter local linkage disequilibrium patterns, suppress recombination, and complicate fine-mapping or haplotype interpretation.

Example usage

"The association signal fell inside a common inversion region with extended LD."

Linkage Disequilibrium (LD) Structural Variant Translocation
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Sudmant PH, et al. (2015). An integrated map of structural variation in 2,504 human genomes. Nature.
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