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Translocation

Definition
AI-generated

A translocation is a structural rearrangement in which a genomic segment is moved to a different chromosomal location, sometimes between chromosomes.

Topics
Core genetics
Related
Duplication Inversion Structural Variant

Why it matters in GWAS

Translocations are more prominent in cytogenetics and cancer genomics than in standard SNP GWAS, but they are still part of the broader variant landscape and can disrupt genes or regulation.

Example usage

"Long-read sequencing was used to resolve a translocation affecting the candidate region."

Duplication Inversion Structural Variant
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Sudmant PH, et al. (2015). An integrated map of structural variation in 2,504 human genomes. Nature.
← Translation Transmission Disequilibrium Test (TDT) →

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