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Precision Oncology

Definition
AI-generated

Precision oncology matches cancer prevention, diagnosis, or therapy to tumor and germline molecular profiles—somatic mutations, copy number, expression, HLA and immune features, and sometimes polygenic germline context—rather than treating all patients with the same histology identically.

Topics
Precision medicine
Related
Biomarker Companion Diagnostics Genome-Wide Association Study (GWAS)

Why it matters in GWAS

Germline GWAS informs susceptibility, toxicity, and trait overlap; tumor cohorts link somatic genetics to outcomes. Translational studies must separate germline from somatic signal, account for ancestry in reference panels, and align variant interpretation with companion diagnostic standards where therapies are targeted.

Example usage

"The precision-oncology board reviewed somatic panel results and matched the patient to a trial arm."

Biomarker Companion Diagnostics Genome-Wide Association Study (GWAS) Immunotherapy Precision Medicine
Related-term network

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References

  • Garraway LA. (2013). Genomic alterations and targeted therapy across subtypes of breast cancer. Nat Genet.
  • Hyman DM, Taylor BS, Baselga J. (2017). Implementing genome-driven oncology. Cell.
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