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Heterozygote disadvantage

Definition
AI-generated

Lower fitness of heterozygotes relative to homozygotes—underdominance or incompatibility contexts.

Topics
Population genetics
Related
Underdominance Speciation Heterozygote

Why it matters in GWAS

Population structure, demographic history, and mating patterns affect allele frequencies, LD, relatedness, and cross-cohort portability—central to GWAS design and interpretation.

Example usage

"Genotype QC and interpretation explicitly accounted for Heterozygote disadvantage status at candidate loci."

Underdominance Speciation Heterozygote
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Hartl DL, Clark AG. (2007). Principles of Population Genetics. Sinauer Associates.
  • Jobling MA, Hurles ME, Tyler-Smith C. (2013). Human Evolutionary Genetics. Garland Science.
← Heterozygote Deficit Heterozygote Excess →

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