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Underdominance

Definition
AI-generated

Heterozygote fitness below homozygotes—polymorphism maintenance requires spatial structure or other mechanisms.

Topics
Population genetics
Related
Heterozygote Disadvantage Natural Selection Structural Variant

Why it matters in GWAS

Population structure, demographic history, and mating patterns affect allele frequencies, LD, relatedness, and cross-cohort portability—central to GWAS design and interpretation.

Example usage

"The methods section includes Underdominance to support interpretation of the primary findings."

Heterozygote Disadvantage Natural Selection Structural Variant
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Hartl DL, Clark AG. (2007). Principles of Population Genetics. Sinauer Associates.
  • Jobling MA, Hurles ME, Tyler-Smith C. (2013). Human Evolutionary Genetics. Garland Science.
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