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Effective Sample Size

Definition
AI-generated

Effective sample size summarizes how much independent information a study contributes compared to an idealized design of unrelated individuals.

Topics
Probability and inference
Related
Genome-Wide Association Study (GWAS) Quality Control (QC) Statistical Power

Why it matters in GWAS

Power calculations, precision of effect estimates, and comparison across studies depend on effective rather than nominal N; duplicate samples and relatedness reduce effective independence.

Example usage

"Results report Effective Sample Size to quantify signal strength and uncertainty alongside p-values."

Genome-Wide Association Study (GWAS) Quality Control (QC) Statistical Power
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References

  • Winkler TW, et al. (2014). Quality control and conduct of genome-wide association meta-analyses. Nat Protoc.
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