Skip to content

Cross-ancestry allele frequency

Definition
AI-generated

Cross-ancestry allele frequency compares or harmonizes allele counts across genetically differentiated groups, often to prioritize variants for multi-ancestry GWAS or to check reference panels.

Topics
Sequencing Data Analysis
Related
Allele frequency Genome Aggregation Database (gnomAD) Multi-ancestry

Why it matters in GWAS

Frequency databases dominated by one ancestry misrepresent others; WGS reference panels increasingly report ancestry-specific AF.

Example usage

"Cross-ancestry allele frequency contrasts used gnomAD ancestry-specific bins before trans-ancestry meta-analysis."

Allele frequency Genome Aggregation Database (gnomAD) Multi-ancestry Trans-ancestry
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Karczewski KJ, et al. (2020). The mutational constraint spectrum quantified from variation in 141,456 humans. Nature.
← Cross-ancestry Cross-Ancestry Genetic Correlation →

Last updated (UTC · Git history)