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Apoptosis

Definition
AI-generated

Programmed cell death executed by intracellular pathways; relevant to tissue homeostasis and some disease mechanisms.

Why it matters in GWAS

GWAS hits are interpreted through gene structure, regulation, and variant consequence; molecular vocabulary connects association statistics to mechanism.

Example usage

"Risk-allele carriers showed higher caspase-3 activity after oxidative stress, consistent with increased apoptosis sensitivity."

References

  • Griffiths AJF, et al. (2015). An Introduction to Genetic Analysis. W. H. Freeman.

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