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Analysis of variance (ANOVA)

Definition
AI-generated

Partitioning total variance into between-group and within-group components via F-tests; common in lab and pathway-style factor experiments adjacent to genetics.

Why it matters in GWAS

Statistical concepts underpin GWAS significance, effect estimation, relatedness random effects, multiple testing, fine-mapping priors, and post-GWAS multivariate methods.

Example usage

"We ran ANOVA to test whether mean expression differed across treatment arms before conducting SNP-by-treatment interaction analysis."

References

  • Casella G, Berger RL. (2002). Statistical Inference. Duxbury Press.
  • Wasserman L. (2004). All of Statistics. Springer.

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