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All of Us Research Program

Definition
AI-generated

All of Us is a U.S.

Topics
Cohorts and databases
URL
https://allofus.nih.gov/
Related
Ancestry Global Biobank Meta-analysis Initiative (GBMI) Genome-Wide Association Study (GWAS)

Why it matters in GWAS

It increases the scale of ancestrally diverse genome-wide association and pharmacogenomic discovery in the United States and supports studies of polygenic risk score portability and health disparities when paired with careful social and environmental context.

Example usage

"This analysis used All of Us Research Program whole-genome and EHR data to replicate lipid-associated loci across diverse U.S. participants."

Ancestry Global Biobank Meta-analysis Initiative (GBMI) Genome-Wide Association Study (GWAS) Participation Bias Polygenic Risk Score Portability Trans-Ancestry GWAS
Related-term network

Click any node to open that term page.

Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • All of Us Research Program Genomics Investigators. (2024). Genomic data in the All of Us research program. Nature.
  • Kuchenbaecker K, Navoly G. (2026). Ancestral diversity in complex disease genetics: from discovery to translation. Nat Rev Genet. https://doi.org/10.1038/s41576-025-00921-3
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