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Transfer Learning

Definition
AI-generated

Transfer learning reuses representations or weights trained on a source domain or task (often large-scale pretraining) and adapts them to a target task with fine-tuning, feature extraction, or prompting, improving data efficiency when labels are scarce.

Why it matters in GWAS

Biomedical foundation models (genomic sequence, protein, text) are typically transfer-learned to variant scoring, single-cell annotation, or cohort-specific phenotyping. Performance and fairness across ancestries depend on source data diversity; fine-tuning on small biased cohorts can harm portability.

Example usage

"The methods section includes Transfer Learning to support interpretation of the primary findings."

References

  • Pan SJ, Yang Q. (2010). A survey on transfer learning. IEEE Trans Knowl Data Eng.

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