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Satellite DNA

Definition
AI-generated

Satellite DNA refers to highly repetitive DNA composed of many tandemly repeated sequences, often located in centromeric or pericentromeric regions.

Topics
Molecular biology
Related
Long-Read Sequencing Repeat Expansion Tandem Repeat

Why it matters in GWAS

Satellite-rich regions are difficult to assay and map with standard technologies, so variation in these regions is often underrepresented in conventional GWAS datasets.

Example usage

"The locus bordered satellite DNA, which complicated read mapping and variant interpretation."

Long-Read Sequencing Repeat Expansion Tandem Repeat
Related-term network

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Node order. The current term is first. Next come every page linked from Related terms, in the same top-to-bottom order as that list. Then new terms appear in two-hop layers: for each of those direct neighbors (in that same order), their related terms are appended if not already listed. A third pass does the same for two-hop nodes. The walk stops when a fixed maximum number of nodes is reached.

References

  • Melters DP, et al. (2013). Comparative analysis of tandem repeats from hundreds of species reveals unique insights into centromere evolution. Genome Biol.
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