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Phosphorylation

Definition
AI-generated

Kinase-driven addition of phosphate groups regulating protein activity and signaling cascades.

Why it matters in GWAS

GWAS hits are interpreted through gene structure, regulation, and variant consequence; molecular vocabulary connects association statistics to mechanism.

Example usage

"A replication analysis checks whether assumptions tied to Phosphorylation hold across cohorts."

References

  • Griffiths AJF, et al. (2015). An Introduction to Genetic Analysis. W. H. Freeman.

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